Hydroxypropyl Beta Cyclodextrin HPBCD CAS 128446-35-5 Pharmaceutical Excipient Food Additive Cosmetic Ingredient
HPBCD
Hydroxypropyl Beta Cyclodextrin (HPBCD, CAS 128446-35-5) is a chemically modified β-cyclodextrin derivative with significantly enhanced water solubility (>600 mg/mL). It functions as a molecular encapsulation agent, forming inclusion complexes with hydrophobic or unstable active ingredients to improve their solubility, bioavailability, and stability
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Product Overview
| Item | Details |
|---|---|
| Product Name | Hydroxypropyl Beta Cyclodextrin (HPBCD) |
| Synonyms | 2-Hydroxypropyl-β-Cyclodextrin; HP-β-CD; Hydroxypropyl Betadex |
| CAS No. | 128446-35-5 / 94035-02-6 |
| Molecular Formula | (C₆H₁₀O₅)₇·(C₃H₇O)ₙ (average) |
| Molecular Weight | ~1,400 – 1,600 g/mol (varies with molar substitution) |
| HS Code | 2940.00 |
| Grade | Pharmaceutical / Food / Cosmetic |
Physical & Chemical Properties
| Parameter | Specification |
|---|---|
| Appearance | White to off-white amorphous powder |
| Odor | Odorless |
| Solubility (Water) | >600 mg/mL (highly soluble) |
| pH (10% aq. sol.) | 5.0 – 8.0 |
| Moisture Content | ≤10.0% |
| Optical Rotation | +150° to +180° (c=1, water) |
| Melting Point | >200 °C (decomposition) |
| Bulk Density | ~0.5 – 0.7 g/cm³ |
| Vapor Pressure | Negligible |
| Log Kow | <0 (hydrophilic) |
Quality Specifications
| Test Item | Method | Specification |
|---|---|---|
| Appearance | Visual | White to off-white powder |
| Identification | IR / NMR | Conforms to reference |
| Molar Substitution (MS) | NMR | 0.4 – 1.5 (typically 0.6–0.9) |
| pH (10% aq. sol.) | pH Meter | 5.0 – 8.0 |
| Water Content | Karl Fischer | ≤10.0% |
| Residue on Ignition | Ph.Eur./USP | ≤0.2% |
| Heavy Metals (as Pb) | ICP-MS | ≤5 ppm |
| Propylene Oxide | GC-HS | ≤1 ppm |
| Microbial Limits (Total) | USP<61> | ≤100 CFU/g |
| Endotoxins (Inj. grade) | LAL | <0.25 EU/mg |
| Clarity of Solution (10%) | Visual | Clear, colorless |
Applications
| Industry | Application | Function |
|---|---|---|
| Pharmaceutical | Drug solubilization, inclusion complex formation, sustained-release formulations | Enhances solubility, bioavailability & stability; reduces toxicity |
| Food | Encapsulation of nutrients, flavors, and active ingredients | Masks off-flavors; extends shelf life; improves stability |
| Cosmetics | Stabilizer, emulsifier, deodorizer in skincare & fragrance | Reduces irritation; enhances fragrance release & longevity |
